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Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching.

J. Virol.. 2019; 
JeevaSubbiah,MirSheema,VelasquezAdrain,WeathersBrandy A,LekaAljona,WuSharon,SevaranyAriga Tahmasian,MirMoha
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摘要

The hantavirus RNA-dependent RNA polymerase (RdRp) snatches 5' capped mRNA fragments from the host cell transcripts and uses them as primers to initiate transcription and replication of the viral genome in the cytoplasm of infected cells. Hantavirus nucleocapsid protein (N protein) binds to the 5' caps of host cell mRNA and protects them from the attack of cellular decapping machinery. N protein rescues long capped mRNA fragments in cellular P bodies that are later processed by an unknown mechanism to generate 10- to 14-nucleotide-long capped RNA primers with a 3' G residue. Hantavirus RdRp has an N-terminal endonuclease domain and a C-terminal uncharacterized domain that harbors a binding site for the N protei... More

关键词

cap snatching,hantavirus,negative-strand RNA virus,nucleoca