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High expression of beta2-glycoprotein I is associated significantly with the earliest stages of hepatitis B virus infection.

J Med Virol. 2014; 
Liu YM, Zhang WY, Wang ZF, Yan CY, Gao PJ.
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摘要

Human beta2-glycoprotein I (beta2-GPI) binds to recombinant hepatitis B surface antigen (rHBsAg) and can bind specifically to annexin II, which is located on the cell membrane of human hepatoma SMMC-7721 cells. Viral envelope proteins are essential for mediating cellular entry. The aim of this study was to investigate the role of beta2-GPI in the early stages of hepatitis B virus (HBV) infection. Western blot and qRT-PCR analyses revealed that beta2-GPI expression was upregulated in HepG2.2.15 cells at both the mRNA and protein level and was almost non-existent in 293T and CHO cells. Furthermore, annexin II was expressed at lower levels in HepG2.2.15 cells compared to L02, HepG2, and SMMC-7721 cells. Additional... More

关键词

annexin II; beta2-GPI; hepatitis B surface antigen; hepatitis B virus; hepatocyte; sodium taurocholate co-transporting polypeptide