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Neuroserpin regulates human T cell-T cell interactions and proliferation through inhibition of tissue plasminogen activator.

J Leukoc Biol. 2020; 
Loef EJ,, Brooks AES,, Lorenz N,, Birch NP,, Dunbar PR,.
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Catalog Antibody Pro- tein samples were fractionated on 12% SDS-PAGE gel and analyzed by Western blotting using anti-annexin A2 (ab41803, Abcam, Cam- bridge, United Kingdom) and anti-b-actin (A00702-100, GenScript, Piscataway, NJ, USA) antibodies. Get A Quote

摘要

T cells play a key role in mounting an adaptive immune response. T cells are activated upon recognition of cognate Ag presented by an APC. Subsequently, T cells adhere to other activated T cells to form activation clusters, which lead to directed secretion of cytokines between communicating cells. T cell activation clusters have been implicated in regulating activation, proliferation, and memory formation in T cells. We previously reported the expression of the protease inhibitor neuroserpin by human T cells and showed that expression and intracellular localization is regulated following T cell activation. To gain a better understanding of neuroserpin in the proteolytic environment postactivation we assessed it... More

关键词

Annexin A2; Cytoskeleton; Immunological synapse; Myosin II ATPase; Plasmin; ROCK signaling; T cell activation