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Ablation of conceptus PTGS2 expression does not alter early conceptus development and establishment of pregnancy in the pig†.

Biol Reprod. 2019; 
Pfeiffer CA, Meyer AE, Brooks KE, Chen PR, Milano-Foster J, Spate LD, Benne JA, Cecil R, Samuel MS, Ciernia LA, Spinka CM, Smith MF, Wells KD, Spencer TE, Prather RS, Geisert RD.
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摘要

Pig conceptuses secrete estrogens (E2), interleukin 1 beta 2 (IL1B2), and prostaglandins (PG) during the period of rapid trophoblast elongation and establishment of pregnancy. Previous studies established that IL1B2 is essential for rapid conceptus elongation, whereas E2 is not essential for conceptus elongation or early maintenance of the corpora lutea. The objective of the present study was to determine if conceptus expression of prostaglandin-endoperoxide synthase 2 (PTGS2) and release of PG are important for early development and establishment of pregnancy. To understand the role of PTGS2 in conceptus elongation and pregnancy establishment, a loss-of-function study was conducted by editing PTGS2 using CRISP... More

关键词

Conceptus; Implantation; PTGS2; Pig; Pregnancy; Prostaglandins