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Decreased human antigen R expression confers resistance to tyrosine kinase inhibitors in epidermal growth factor receptor-mutant lung cancer by inhibiting Bim expression

Int J Mol Med. 2018; 
Yao Y, Chu H, Wang J, Wang B.
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Recombinant Proteins … 1:5,000; Santa Cruz Biotechnology, Inc.) and HRP‑conjugated mouse anti‑rabbit IgG (cat. no. A01827‑200; 1:5,000; Genscript, Piscataway, NJ, USA). The blots were visualized using an enhanced chemiluminescence kit (Beyotime Institute of Biotechnology, Shanghai, China) … Get A Quote

摘要

Primary resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) is an obstacle for the treatment of non‑small cell lung cancer (NSCLC); however, the associated mechanisms are not well understood. Studies have reported that Bim expression levels may be associated with the efficacy of EGFR‑TKI treatment in NSCLC patients harboring EGFR mutations. Human antigen R (HuR) regulates the mRNA and protein expression of target genes, including certain B‑cell lymphoma 2 family members. The present study investigated whether HuR mediates resistance to EGFR‑TKIs via the regulation of Bim. The results demonstrated that decreased levels of HuR and Bim protein expression are associat... More

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