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Ndufa6 regulates adipogenic differentiation via Scd1

Adipocyte. 2021-12; 
Jingwei Zhang, Wei Wang, Ninghan Feng, Xuan Jiang, Shenglong Zhu, Yong Q Chen
Products/Services Used Details Operation
Recombinant Proteins epidermal growth factor (EGF, GenScript, Z02972), fibroblast growth factor-basic (bFGF, GenScript Biotech, Z03016), Get A Quote

摘要

Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-C... More

关键词

Ndufa6; Obesity; Scd; adipogenic differentiation.