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Antiviral RNA interference in disease vector (Asian longhorned) ticks

PLoS Pathog. 2021-12; 
Yan Xu, Zhengwei Zhong, Yanxin Ren, Liting Ma, Zhi Ye, Chuang Gao, Jingwen Wang, Yang Li
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Proteins, Expression, Isolation and Analysis Western and Northern blotting analysis were performed as described previously [92]. Anti-Flag mAb was purchased from GenScript (A01428-100).  Get A Quote

摘要

Disease vectors such as mosquitoes and ticks play a major role in the emergence and re-emergence of human and animal viral pathogens. Compared to mosquitoes, however, much less is known about the antiviral responses of ticks. Here we showed that Asian longhorned ticks (Haemaphysalis longicornis) produced predominantly 22-nucleotide virus-derived siRNAs (vsiRNAs) in response to severe fever with thrombocytopenia syndrome virus (SFTSV, an emerging tick-borne virus), Nodamura virus (NoV), or Sindbis virus (SINV) acquired by blood feeding. Notably, experimental acquisition of NoV and SINV by intrathoracic injection also initiated viral replication and triggered the production of vsiRNAs in H. longicornis. We demons... More

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