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Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase

CNS Neurosci Ther. 2021-08; 
Huan Chen, Yan Teng, Xingmin Chen, Zhihao Liu, Fan Geng, Yanzhuo Liu, Haisong Jiang, Ziyan Wang, Lu Yang
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摘要

aims: The neurotropic growth factor PDGF-BB was shown to have vital neurorestorative functions in various animal models of Parkinson's disease (PD). Previous studies indicated that the regenerative property of PDGF-BB contributes to the increased intensity of tyrosine hydroxylase (TH) fibers in vivo. However, whether PDGF-BB directly modulates the expression of TH, and the underlying mechanism is still unknown. We will carefully examine this in our current study. method: MPTP-lesion mice received PDGF-BB treatment via intracerebroventricular (i.c.v) administration, and the expression of TH in different brain regions was assessed by RT-PCR, Western blot, and immunohistochemistry staining. The molecular mechanism... More

关键词

PDGF-BB, Parkinson's disease, dopaminergic neuron, tyrosine hydroxylase