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NRXN1 depletion in the medial prefrontal cortex induces anxiety-like behaviors and abnormal social phenotypes along with impaired neurite outgrowth in rat

J Neurodev Disord. 2023-02; 
Di Wu, Jiansheng Zhu, Lianghui You, Jingyu Wang, Sufen Zhang, Zhonghui Liu, Qu Xu, Xiaojie Yuan, Lei Yang, Wei Wang, Meiling Tong, Qin Hong, Xia Chi
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Molecular Biology Reagents … Denatured protein samples were separated with 4–12% (GenScript, M00653) sodium … -associated virus vectors targeting NRXN1. The diffusion range of the GFP-reporter virus vectors … Get A Quote

摘要

background: Neurodevelopmental disorders (NDDs) are a group of disorders induced by abnormal brain developmental processes. The prefrontal cortex (PFC) plays an essential role in executive function, and its role in NDDs has been reported. NDDs are associated with high-risk gene mutations and share partially overlapping genetic abnormalities. methods: Neurexins (NRXNs) are related to autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). NRXN1, an essential susceptibility gene for NDDs, has been reported to be associated with NDDs. However, little is known about its key role in NDDs. results: NRXN1 downregulation in the medial PFC induced anxiety-like behaviors and abnormal social ph... More

关键词

Anxiety-like behavior, Cell adhesion molecules, NRXN1, Neurite outgrowth, Neurodevelopmental disorders, Social behavior