黄金城集团

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop

Adv Sci (Weinh) . 2024-05; 
Rongze Ma, Deyi Feng, Jing Chen, Jiecan Zhou, Kun Xia, Xiangyin Kong, Guohong Hu, Pengfei Lu
Products/Services Used Details Operation
Gene Synthesis After the cells were cultured as spheres in the stem cell medium, they were placed in a sphere containing 2% Growth factor, starved for 24 h in the basic medium of reduced Matrigel, treated with FGF2, FGF7 (GenScript, Z03154), or FGF10 (GenScript, Z03155) (50 ng mL−1) or BMP7 (50 ng mL−1) for 24 h, before RNA or proteins were extracted for downstream experiments. Get A Quote

摘要

Tumor heterogeneity, the presence of multiple distinct subpopulations of cancer cells between patients or among the same tumors, poses a major challenge to current targeted therapies. The way these different subpopulations interact among themselves and the stromal niche environment, and how such interactions affect cancer stem cell behavior has remained largely unknown. Here, it is shown that an FGF-BMP7-INHBA signaling positive feedback loop integrates interactions among different cell populations, including mammary gland stem cells, luminal epithelial and stromal fibroblast niche components not only in organ regeneration but also, with certain modifications, in cancer progression. The reciprocal dependence of... More

关键词

BMP signaling; FGF signaling; drug resistance; individualized medicine; intra‐tumoral heterogeneity; microenvironment; precision medicine; targeted therapy.