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BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.

Cell Cycle. 2014; 
Zhao H, Zhu M, Dou G, Zhao H, Zhu B, Li J, Liao J, Xu X.
Products/Services Used Details Operation
Monoclonal Antibody Services … Bethyl; mouse monoclonal antibodies anti-γ-H2AX, rabbit polyclonal antibodies anti-RNF168 (ABE367) for IF, anti-RNF168 (06-1130) for IP, and anti-ubiquitin (FK2) were from Millipore; rabbit monoclonal antibody anti-GST (A00865) was from GenScript; mouse monoclonal … Get A Quote

摘要

Timely and proper cellular response to DNA damage is essential for maintenance of genome stability and integrity. B-cell lymphoma/leukemia 10 (BCL10) facilitates ubiquitination of NEMO in the cytosol, activating NFκB signaling. Translocation and/or point mutations of BCL10 associate with mucosa-associated lymphoid tissue lymphomas and other malignancies. However, the mechanisms by which the resulting aberrant expression of BCL10 leads to cellular oncogenesis are poorly understood. In this report, we found that BCL10 in the nucleus is enriched at the DNA damage sites in an ATM- and RNF8-dependent manner. ATM-dependent phosphorylation of BCL10 promotes its interaction with and presentation of UBC13 to RNF8, and ... More

关键词

BCL10; DNA damage; RNF168; RNF8; ubiquitination